Endocrine Abstracts

Screening for complications and associated conditions in children with type 1 diabetes is routinely performed in Diabetes Clinics. Though there are NICE recommendations screening tests, interpretation and management is varied as there is no strong evidence base in paediatrics. We conducted a survey across diabetes units to establish the prevailing practice.Method: Survey monkey questionnaire was sent out to clinicians who care for children with diabetes ...

Case history: A 41-year-old lady had Total Thyroidectomy in 2007 for a large multi-nodular goitre. Post-operatively, she was hypocalcemic with mild inappropriately low Pth levels. She was treated with high dose α-calcidol and calcium supplements but the response was suboptimal. Following introduction of teriparatide, serum calcium has been improving to between 1.90 and 2.06 mmol/l. She continues on high dose α-calcidol.Investigations: Corrected...

Objective: To investigate the effects of BPA on oxidative damage in terms of activity level of antioxidant enzymes in different regions of the rat brain.Background: The ever increasing uses of electronic gadgets are becoming a widespread source of bisphenol-A accumulation. As studies have been reported that low level BPA accumulation may produce neurological effects but still limited studies have re-examined for its adverse effects in terms of acute expo...

Introduction: Epilepsy and anti-epileptic medications can be associated with various endocrine disorders namely, polycystic ovary syndrome, premature ovarian failure, hypothalamic amenorrhoea, functional hyperprolactinaemia and rarely galactorrhoea. Here, we present a lady who developed intermittent episodes of galactorrhoea suspected to be due to primary generalized seizures.Case report: A 50-year-old lady was referred for investigation of elevated prol...

Introduction: Type 2 diabetes mellitus (T2DM) is an independent risk factor for uric acid nephrolithiasis and obesity augments this risk. We studied 25 T2DM patients to assess the risk factors for uric acid nephrolithiasis and their relation with metabolic syndrome.Methods: In this cross-sectional study, 25 patients of T2DM were included and examined for components of metabolic syndrome. A single 24 h urine sample was analyzed for uric acid, creatinine a...

Introduction: Obesity effects pituitary–thyroid axis resulting in elevated thyroid stimulating hormone (TSH) level. We studied the relation between body mass index (BMI) and TSH in euthyroid and subclinical hypothyroid obese children and compared serum TSH level among obese and overweight children.Methods: Fifty consecutive children (aged 2–18 years) presenting for obesity were studied. All cases with TSH >10, low T3/T4</sub...

HHS is a rare hyperglycaemic emergency, typically precipitated by infection in people with T2DM. There are few recorded cases of COVID induced pure HHS. We here by report 2 further cases, including the first known reported case in a person with T1DM.Case 1: 81yo male with T1DM (on glargine and aspart insulin, HbA1c 57 mmol/mol) presentedwith lethargy, general deterioration and a fall.Therewere no new symptoms offever/cough/breathlessness or change in tas...

Background: About 20% of thyroid-nodules have indeterminate-cytology (IDC), classified as Bethesda categories-III/ IV. They carry varying risks of malignancy (6-18%, 10-40% respectively). Ideal test to determine the risk of malignancy in IDC is unclear. Molecular-profiling has shown promise, but availability & affordability is an issue. We aim to evaluate diagnostic value of modified systemic inflammation score(mSIS) to determine malignancy in IDC.Me...

Background: Appropriate management of thyroid diseases is crucial, as outcomes directly affect quality-of-life. High-volume thyroid surgeons provide best results, least complications. We aim to assess if a dedicated endocrine-surgery unit influences treatment-decisions(TD) of patients in an endocrine-surgeon naïve area.Method: Study of 153-patients at Maax Superspecialty Hospitals(Shivamogga, India), from November/2021-October/2023. Previously diagn...

Neonatal autoimmune hyperthyroidism is rare but potentially fatal condition. It occurs in 1-5% of infants born to pregnant mothers with Graves’ disease (GD). We present a case of transient neonatal thyrotoxicosis born to pregnant women with GD and high TSH Receptor antibodies. 42 years pregnant lady was referred to Antenatal Endocrine clinic at Walsall Manor Hospital in 15th week of pregnancy with symptoms of Thyrotoxicosis. She has GD and was taking Propylthio...